WebJul 29, 2024 · Chromosomal instability (CIN) is a key genomic driver of human cancer. CIN generates genomic copy-number heterogeneity and tumor-derived inflammation. In a recent paper, Hong et al. identify the cGAS–STING innate immune pathway as a crucial dependency in cancer cells with CIN and pinpoint the IL6/STAT3 axis as a therapeutic … WebFeb 1, 2024 · The proinflammatory cytokine IL6 is known to activate STAT3 signaling, and CIN induction in cancer cells increases IL6 expression. In fact, the authors find that IL6 induction requires CIN-induced cGAS/STING and downstream non-canonical NF-κB because it can be prevented by knocking out cGAS, STING, or RELB.
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WebJun 22, 2024 · Regulation of cGAS-STING pathway in tumor promotion. The cGAS-STING pathway could exert its pro-tumor role in metastatic tumor settings. STING functions as a platform for different tumorigenic programs. High chromosome instability (CIN) tumors generated micronuclei, and its rupture could release DNA to the cytosol, enhancing the … WebChromosomal instability (CIN) is an intrinsic feature of cancer, and results spontaneously from errors in chromosome segregation during the mitosis of cancer cells. CIN can also … impulsiveness in adhd
Chromosomal instability as central hallmark of Breast Cancer BCTT
WebThe connection between CIN and the cGAS-STING pathway raises the exciting possibility that chromosome segregation errors could serve as a trigger of immune editing during the early steps of tumorigenesis. … WebAug 27, 2024 · The cGAS-STING DNA sensing signaling pathway. Various DNA derived from virus, dying tumor cells or nucleus and mitochondria binds to and activates the cytosolic DNA sensor cGAS, cGAS catalyzes the synthesis of 2′3′-cGAMP in the presence of ATP and GTP, then 2′3′-cGAMP binds to the ER adaptor STING, which also can be … WebApr 12, 2024 · The authors demonstrate how the combination of CIN, TMB, and cGAS-STING activation tumor suppression of infiltrating immune cells may represent a discrete mechanism of immune evasion. The authors specifically investigate the interaction between the cGASSTING pathway, tumor inflammation, CIN, TMB, and response to immunotherapy. lithium gate motor battery