Cisdiamminedichloroplatinum

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WebSep 1, 1990 · The specific drug combination and experimental growth system for this introductory application was that of 1-β- d -arabinofuranosylcytosine (ara-C) and cisplatin with simultaneous drug exposure (1, 3, 6, 12, or 48 h) against L1210 leukemia in vitro. WebApr 19, 2024 · A platinum-based chemotherapeutic agent, Cisplatin (CDDP), has been widely used to treat many human cancer including cervical cancer, metastatic cancers and most of other solid tumors [1]. The cisplatin anticancer efficacy is owing to its interaction with chromosomal DNA.

What is the geometry of cis-diamminedichloroplatinum (II)?

WebThe thioredoxin (TRX) system, composed of nicotinamide adenine dinucleotide phosphate (reduced form), TRX, and TRX reductase (TRXR), has multiple biologic functions via thiol-mediated redox control. In this study, we investigated the relationship between intracellular TRXR levels and cellular sensitivity to cis-diamminedichloroplatinum (II) (CDDP). Webcis-Diamminedichloroplatinum(II): effects of a representative metal coordination complex on mammalian cells Pharmacol Ther. 1984;25(3):297-326.doi: 10.1016/0163 … immersive reader outlook web

Cisplatin (cisdiamminedichloroplatinum) for treatment of …

WebNov 1, 1983 · cis -Platinum, bleomycin, 5-fluorouracil, and cyclophosphamide were administered to rodent and canine models of osmotic blood-brain barrier modification to evaluate the relationship between tissue drug concentration in brain and the physiological and neuropathological effects of the drug. Webcis-Diamminedichloroplatinum(II): effects of a representative metal coordination complex on mammalian cells Pharmacol Ther. 1984;25(3):297-326.doi: 10.1016/0163-7258(84)90003-2. Author E B Douple PMID: 6542679 DOI: 10.1016/0163-7258(84)90003-2 No abstract available Publication types WebCis-diamminedichloroplatinum (II) (DDP) leads the series of platinum coordination complexes, a new class of cytotoxic agents. The antitumor and toxic effects of this drug … immersive reading

trans-Platinum(II) diamminedichloride Cl2H6N2Pt+2

Cisplatin (cis-diamminedichloroplatinum II) - PubMed

WebFeb 25, 2016 · Platinum, being a 5d metal, has d orbitals that are larger than the 3d orbitals, allowing for a more spread out electron density. That decreases the coulombic repulsion energy, which we will call Πc. The … WebCisplatin (cis-diamminedichloroplatinum) is an alkylating agent and a subset of platinum (II) analogs. It acts by producing an immensely reactive moiety that facilitates the cross … immersive reader word where to findWebAbstract Murine leukemia L1210 cells, either sensitive or resistant to the toxic action of the cancer chemotherapeutic agent cis-diamminedichloroplatinum (II), have been studied … immersive reader word 365

"WebShort-term cis-diamminedichloroplatinum(II) accumulation in sensitive and resistant human ovarian carcinoma cells We examined the short-term accumulation of cisplatin (DDP) in sensitive 2008 human ovarian carcinoma cells and in a 2- to 3-fold DDP-resistant and accumulation-deficient variant. " - Cisdiamminedichloroplatinum

Cisdiamminedichloroplatinum

Analysis of resistance-associated gene expression in docetaxel ...

Web1-β-D-Arabinofuranosylcytosine (ara-C) and hydroxyurea (HU) were investigated as possible inhibitors for the repair of cis-diamminedichloroplatinum(II) (DDP)-induced DNA damage. HU and ara-C were chosen for their known ability to … WebJun 1, 1973 · cis -Diamminedichloroplatinum (II) is the first of a group of platinum coordination complexes with antineoplastic activity to be studied in humans. This Phase I investigation characterizes the toxicity and pharmacological disposition of …

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WebA total of 26 patients with biopsy proved epidermoid carcinoma of the penis (Jackson stage III or IV) with measurable disease, no prior chemotherapy and adequate renal function … WebJan 1, 1987 · Abstract. Human ovarian cancer cell lines with stable cisplatin resistance have been developed by chronic exposure of the parent cisplatin-sensitive A2780 line to increasing concentrations of cisplatin. 2780CP8 (CP8 refers to this cell line's growth in medium containing 8 µm cisplatin) has several clonal cytogenetic abnormalities but lacks …

WebSpectrum of cis-diamminedichloroplatinum (II)-induced mutations in a shuttle vector propagated in human cells Spectrum of cis-diamminedichloroplatinum (II)-induced mutations in a shuttle vector propagated in human cells Authors G J Bubley 1 , B P Ashburner , B A Teicher Affiliation WebDec 1, 1992 · To elucidate the mechanism of the synergistic cytotoxicity of 5-fluorouracil (5-FU) and cis-diamminedichloroplatinum (II) (CDDP), we studied the interaction of these agents using a human squamous carcinoma cell line (HST-1).

WebApr 20, 2016 · miR-3188 suppresses cell growth and 5-FU chemoresistance. To identify the role of miR-3188 in NPC development, we first examined its expression levels in normal epithelium (NP) and NPC cell lines. miR-3188 expression was elevated in NP69 and SXSW-1489 cells but weakly expressed in NPC cells (Fig. 1a).To further explore its biological … WebCisplatin (cis-Diamminedichloroplatinum) is a organometallic compound and one of several platinum-based antineoplastic agents used in certain types of chemotherapy for the treatment of cancer. These compounds, …

WebAbstract Cis-diamminedichloroplatinum (DDP) was used as the initial treatment in a pilot study of 17 patients with biopsy-proven transitional cell carcinoma of the bladder. No …

WebAbstract. Fifty patients with disseminated testicular cancer were treated with a three-drug combination consisting of cis-diamminedichloroplatinum, vinblastine, and bleomycin. … immersive reader toolsWebWe demonstrated previously that the effect of cis-diamminedichloroplatinum(II) (cisplatin) against pancreatic cancer was substantially enhanced by the addition to the … immersive reader word 2019Webtrans-Platinum(II) diamminedichloride Cl2H6N2Pt+2 CID 441203 - structure, chemical names, physical and chemical properties, classification, patents, literature ... immersive reading outlookWebDec 3, 1979 · [Cis-diamminedichloroplatinum(II). A new antineoplastic agent derived from the group of heavy metal complexes (author's transl)] Platinum coordination complexes represent a new class of antineoplastic agents among which only cis-diamminedichloroplatinum(II) (cis-DDP) has undergone extensive clinical trials. list of state of indiaWebA total of 26 patients with biopsy proved epidermoid carcinoma of the penis (Jackson stage III or IV) with measurable disease, no prior chemotherapy and adequate renal function received 50 mg. per M.2 cis-diamminedichloroplatinum intravenously on days 1 … list of state of being verbsWebA regression rate of 12% (4/33) among patients with advanced upper aerodigestive carcinomas who received an intravenous regimen of cis‐diamminedichloroplatinum, … list of state mineralsWebJun 1, 1975 · Summary. The effects of cis -diamminedichloroplatinum (NSC 119875) on murine and human hemopoietic precursor cells were studied in culture. When murine … immersive recovery encinitas