WebJun 6, 2014 · The results introduce a new paradigm where cytokine treatment prolongs nuclear retention simultaneous with decreasing rather than increasing the rate of nuclear import. ... It would thus appear that the C-terminal tail of STAT3α contributes to cytoplasmic retention of STAT3 in the cytoplasm under basal conditions, with S727 within it helping ... WebThe cytoplasmic retention of the precursor molecule is controlled by a small region in its C-terminal part. We show that this region is responsible for the observed lack of DNA binding of the p50 precursor and controls the extent of …
Sequence Determinants for Nuclear Retention and Cytoplasmic …
WebMar 1, 2013 · A cytoplasm retention signal would, in theory, not be affected by these interventions, whereas we observed nuclear accumulation of Htt in the setting of inhibition of nuclear export. Given its high degree of evolutionary conservation, beyond the four amino acid NES motif, it is highly plausible that N17 contains overlapping, but distinct ... WebOct 17, 2024 · Cytoplasmic fusion is not followed by karyogamy, resulting in a dikaryotic cell. After cell fusion on the plant surface, the G2 cell cycle arrest is sustained, and the single dikaryotic cell grows in a polar … help bgea.org
Role of the Tetradecapeptide Repeat Domain of Human
WebMar 1, 2004 · Cytoplasmic retention of signal transducers prevails when cells are poised to receive an extracellular signal, and nuclear … WebMay 2, 2014 · Currently, it is known that in its inactive state, CAR is retained in the cytoplasm in a protein complex with HSP90 and the tetratricopeptide repeat protein cytosoplasmic CAR retention protein (CCRP). WebOct 17, 2024 · This new understanding of the determinants of nuclear retention and cytoplasmic export provides a deeper understanding of how information flow is regulated in eukaryotic cells. Ultimately these processes promote the evolution of complexity in eukaryotes by shaping the genomic content through constructive neutral evolution. lamb of god mass of creation