WebAdditionally, FSS13025 and R103451 each contained the amino acid substitutions K1059E and K733R, respectively, compared to published sequences (Table S2). Overall, the NGS results provided a rich dataset to perform downstream genetic analysis. Figure 2. ZIKV NGS sequencing dataset description. WebMay 23, 2016 · In this study, a total of six (6) male and female ZIKV and DENV seronegative Cynomolgus macaques were challenged with ZIKV strain isolates PRVABC59, FSS13025 or IBH 30656 subcutaneously (n=2 per strain) with a target delivery dose of approximately 1×10 4 or 5×10 5 PFU per monkey. A description of the viruses used are shown in Table 1.

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WebZika virus (ZIKV) FSS13025 and PRVABC59 strain-specific small RNAs in Aedes albopictus tissues. Size distribution of small RNA from ZIKV-infected mosquito tissues. (A) Sequences mapping to the PR strain (lower) and FS strain (upper) viral genome (red) and antigenome (dark blue) in midguts at 4 d post-exposure (dpe). WebDec 19, 2016 · An intermittent viremia spike was observed on day 30 with titers reaching 2.5 × 10 3 genomes/mL. Moderate viral load was observed in testes, urine and saliva. In contrast, FSS13025 induced viremia lasting only up to 6 days and detectable viral loads in testes but not in urine and saliva. top polyurethane

Shared Molecular Signatures Across Zika Virus Infection and

WebJun 16, 2024 · We next performed siRNA knockdown to reduce Peli1 expression by 41% ( Fig 1D) in HTR8 cells followed by infection with the clinical Asian-lineage FSS13025 strain (ZIKV-FSS13025). WebFSS13025 A V N D T H I R S I V A E A L . . M L PA259249 A V N D T H I R S I V A E A L … pinecone throw blanket