WebJan 28, 2014 · FSTL-1 promotes caspase-1 activation in monocytes and macrophages. Human U937 cells stably transfected with plasmid encoding FSTL1 or a control plasmid … WebResults FSTL1 expression was significantly elevated in macrophages from fibrotic livers of both humans and mice. Myeloid-specific FSTL1 deficiency effectively attenuated the …
11167 - Gene ResultFSTL1 follistatin like 1 [ (human)]
WebNational Center for Biotechnology Information WebJun 1, 2024 · Furthermore, FSTL1 is an acidic cysteine-rich secreted protein and a member of the SPARC family based on protein domain similarity [5]. Indeed, FSTL1 binds to disco-interacting protein2 homolog A (DIP2A), which is a receptor for FSTL1 as evidenced by molecular interaction analyses by Ouchi et al. [6]. boston\u0027s baddest burger food truck
Follistatin‐like protein 1 enhances NLRP3 inflammasome‐mediated …
WebDec 10, 2024 · FSTL1 is a potential mediator of inflammation and insulin resistance in obesity. Fstl1 is crucial for elastin expression and deposition in mesenchyme during lung alveologenesis; These results suggest that FSTL-1 may act on the NLRP3 inflammasome to promote IL-1beta secretion from monocytes/macrophages. WebFSTL1 reduces transcellular transport of LDL-sized particles and of LDL itself, and inhibits endothelial activation. ... (NF-κB), adhesion molecule expression and monocyte … WebFollistatin like-1 (FSTL1) is a secreted glycoprotein involved in a series of physiological and pathological processes. However, its contribution to the development of cancer, especially the pathogenesis of NSCLC, remains to be elucidated. We explored the expression, function, and molecular mechanis … boston\\u0027s basketball team