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Web昼夜节律紊乱与糖代谢紊乱有关，骨骼肌中也存在分子钟。网络振荡器 (Chrono) 和大脑和肌肉 ARNT 样 1 (Bmal1) 的 ChIP 衍生抑制因子是核心的昼夜节律成分。Chrono 被认为是 Bmal1 的阻遏物，Chrono-Bmal1 通路对调节昼夜节律很重要；据推测，该途径可能是一种调节葡萄糖代谢的新机制。
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