WebBCRP belongs to the subfamily G of the ABC transporter superfamily [ 67] and is a 72-kDa half-ABC transporter, consisting of 655 amino acids; it has one TMD with six alpha-helices at the C-terminal end and one NBD at the N-terminal end. WebThe Breast Cancer Resistance Protein (BCRP/ABCG2) belongs to the G class of ABC (ATP-Binding Cassette) proteins, which is known as one of the main transporters involved in the multidrug resistance (MDR) phenotype that confer resistance to anticancer drugs. The aim of this study was to design, synthesize and develop new potent and selective ...
The human breast cancer resistance protein (BCRP/ABCG2) …
Webactual installation equipment and lot of fasteners to be used on the structure, he can properly install them and obtain the proper tension. g. Job inspecting torque (referred to … WebSep 19, 2014 · The human breast cancer resistance protein (BCRP, gene symbol ABCG2) is an ATP-binding cassette (ABC) efflux transporter. It was so named because it was initially cloned from a multidrug-resistant breast cancer cell line where it was found to confer resistance to chemotherapeutic agents such as mitoxantrone and topotecan. Since its … mchenry workforce center
Structure and function of the human breast cancer
WebThe crystal structure of BCRP is unknown and thus the interactions of substrates with the protein cannot be precisely identified (McDevitt et al., 2009; Ni et al., 2010a; Rosenberg et al., 2010). WebBCRP/ABCG2 Protein Overview. The ABCG2 gene encodes a membrane transporter belonging to the ATP-binding cassette (ABC) superfamily of membrane transporters, which are involved in the trafficking of biologic molecules across cell membranes. ABCG2 was initially found to be a xenobiotic transporter that plays a role in the multidrug resistance ... WebMar 1, 2010 · Indeed, little is known about the structure of BCRP, although an atomic model of BCRP was recently predicted by homology modeling based on the crystal structure of the bacterial multidrug exporter Sav1866, which suggested that BCRP had multiple drug binding sites ( Hazai and Bikadi, 2008 ). liberty tool and engineering