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Thbs1 tsp1

Web8 Oct 2024 · TIMP1 (tissue inhibitor of metalloproteinases-1) is upregulated in Thbs1-deficient BMDMs (bone marrow–derived macrophages) and aorta.A–C, Thbs1 +/+ and …

Thrombospondin-1 CD47 Signalling: From Mechanisms to …

WebFull gene name according to HGNC. Thrombospondin 1. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. THBS1 (THBS, … Web27 Jan 2016 · TSP1 plays a complex role in macrophage IL-1β responses that involves CD47 and other TSP1 receptors in addition to its known activation of immunosuppressive TGF … humanitas inloggen nedap https://letmycookingtalk.com

Suppression of Endothelial AGO1 Promotes Adipose Tissue ... - Circulation

WebMice Deficient in Thbs1 Are Resistant to AAA Induction To determine whether thrombospondin-1 contributes to aneurysm pathogenesis, we subjected thrombospondin-1–deficient ( Thbs1−/−) mice to aneurysm induction … Web12 May 2024 · Mechanistically, EC-AGO1 suppression results in inhibition of thrombospondin-1 ( THBS1 /TSP1), an antiangiogenic and proinflammatory cytokine that promotes insulin resistance. In EC-AGO1-KO mice, overexpression of TSP1 substantially attenuated the beneficial phenotype. Web13 Apr 2024 · Here, we identified TSP1V as a novel TSP1-splicing variant produced by intron retention (IR) in human thyroid cancer cells and tissues. We observed that TSP1V functionally inhibited tumorigenesis... humanitas homerun rotterdam

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Category:Thrombospondin-1 Antibody Cell Signaling Technology

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Thbs1 tsp1

21825 - Gene ResultThbs1 thrombospondin 1 [ (house mouse)]

http://yobibio.com/product.asp?anclassid=8&nclassid=53&bookid=4838 Web6 Nov 2024 · These changes include suppression of Thbs1, which encodes thrombospondin1 (TSP1) and has been ascribed to KLF2- and KLF4-mediated repression …

Thbs1 tsp1

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Web006141 B6.129S2- Thbs1 tm1Hyn /J Mice homozygous for this targeted mutation exhibit an increase in the number of circulating white blood cells with monocytes and eosinophils having the largest percent of increase. There is considerable hyperplasia of the various epithelial cell lineages. Mutant mice may be useful in studies of inflammatory responses … Web006141 B6.129S2- Thbs1 tm1Hyn /J Mice homozygous for this targeted mutation exhibit an increase in the number of circulating white blood cells with monocytes and eosinophils …

WebThrombospondin-1 (TSP-1) is a 150-180 kDa calcium-sensitive protein that is secreted as a disulfide-linked homotrimer. Within the Thrombospondin family, TSP-2 is also homotrimeric, while TSP-3, -4, and -5/COMP are homopentameric. Web31 Dec 2024 · Two of the altered genes were of particular interest with respect to PMN formation: thrombospondin‐1 (TSP1; THBS1) was the most significantly downregulated gene, while the chondroitin sulfate proteoglycan, versican (VCAN), was significantly upregulated. ... Reduced TSP1 and elevated VCAN are favourable for PCa tumour cell …

Web21 Mar 2024 · THBS1 (Thrombospondin 1) is a Protein Coding gene. Diseases associated with THBS1 include Thrombotic Thrombocytopenic Purpura and Pseudoachondroplasia . … Web13 Apr 2024 · Thrombospondin 1 (TSP1) is known for its cell-specific functions in cancer progression, such as proliferation and migration. It contains 22 exons that may potentially …

WebPreviously, we demonstrated that macrophages from thrombospondin 1 (TSP1)-deficient mice have a reduced inflammatory phenotype, suggesting that TSP1 plays a role in macrophage activation. In this study, we determined how TSP1 regulates macrophage function. We found that recombinant or purified plate …

Web24 Mar 2024 · 实验原理 （ 1 ）特异性结合抗原：抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞，通常需要补体或吞噬细胞等共同发挥效应以清除病原微生物或导致病理损伤。 然而，抗体可通过与病毒或毒素的特异性结合，直接发挥中和病毒的作用。 （ 2 ）活补体： IgM 、 IgG1 、 IgG2 和 IgG3 可通过经典途径 ... humanitas homerun utrechtWeb21 Apr 2024 · Here we generated Thbs1Flox/Flox mice, which also expressed Cad5- Cre (TSP EC ), Pdgfrb -Cre (TSP PC) or Gfap -Cre (TSP AC) to address the contribution TSP1 … humanitas kinderkampWeb9 Oct 2024 · Background & aims: Thrombospondin 1 (TSP1) is a multifunctional matricellular protein. We previously showed that TSP1 has an important role in obesity … humanitas kennemerland